… binding sites for transcription factors, including hypoxia-inducible … the invasive growth
program, in which cancer cells acquire the ability to disrupt cell-to-cell interactions, migrate through …

… induced the expression and secretion of HGF in PSC via transcription … of pancreatic cancer
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …

… is the hepatocyte growth factor (HGF)/c-MET pathway. HGF … the invasiveness of a pancreatic
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …

… migration, invasion and subsequently promote metastases. … be detected in pancreatic
cancer stem cells, too [56, 67, 68, 69, 70]. … pathway might play an important role in tumor-stromal …

… receptor by its ligand, the hepatocyte growth factor (HGF), … pair sustains the interaction
between cancer cells and the … acts as a pro-invasive factor on pancreatic cancer cells, little is …

… of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate … that
targeting of a specific pathway such as the HGF-c-MET pathway, by inhibiting its active ligand…

… by tumor stromal cells participate in PC progression via … and cell differentiation in response
to stresses including hypoxia… signaling pathways that mediate cancer cell invasion and …

… (PC) by secreting hepatocyte growth factor (HGF). The … modulate proliferation, invasion
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …

… , our results illuminate tumor–stromal interactions, which drive … invasion assay using coculture
of Panc10.05 and hCAF cells … of the hepatocyte growth factor/c-MET pathway in pancreatic …

… into myofibroblasts through the accumulation of the hypoxia-… and invasiveness of primary
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …